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    Unsere Forschungs- und Entwicklungsteams sind weltweit im Einsatz und generieren Synergien aus unserem Expertenwissen und verwandten Fachdisziplinen. Wir stehen im internationalen Austausch mit unabhängigen Fachinstitutionen, Key Opinion Leadern und Multiplikatoren, um so Kooperations- und Wissensmanagement auf höchstem Niveau gewährleisten zu können. Im Rahmen dessen führen wir umfangreiche Forschungen durch, die kontinuierlich auf Kongressen in Form von Postern oder freien Vorträgen unserer Kooperationspartner sowie in Symposien und Workshops präsentiert und in namhaften wissenschaftlichen Fachzeitschriften veröffentlicht werden. Die größtenteils von unabhängigen Gutachtern bewerteten, evidenzbasierten Fachpublikationen, stellen wir Ihnen in dieser Datenbank zur Verfügung:

    1. Poster

      MEASUREMENT OF THE ADHESION DISPOSITION OF ALUMINIUM-COATED DRESSINGS* IN VITRO

      Poster presented at EWMA 2016 11.05.2016 Bremen, Germany

      Aim:

      Coating of wound dressings may prevent their adherence to the wound surface which otherwise would disrupt the wound bed and destroy newly formed, healthy tissue on removal. This happens for example often with simple gauze pad. We have evaluated the adhesion disposition of aluminium-coated dressings in vitro.

       

      Method:

      Three aluminium-coated dressings* were tested. For measurement of the adhesion disposition, a gelatine-based tissue substitute with fibrinogen/thrombin layer was prepared. Dressing samples were cut corresponding to 3x4cm and fixed to a plaster with holding noose for the force gauge. Only the dressing area posing the padding zone was employed for testing. Cotton gauze was treated in the same manner and used as positive control. Evaluation of the adhesion disposition was done by measurement of the force necessary to remove the dressing from the tissue substitute.

       

      Results / Discussion:

      Significantly lower removal forces were needed to detach the dressing samples* from the tissue substitute compared to the positive control cotton gauze. The following order of removal forces for the different dressings was found: cotton gauze (0.72N) >> compress (0.11N) > trachea compress (0.07N) > sheet (0.03N). In accordance, the adhesion disposition determined for the aluminium-coated dressings* was significantly lower than that of cotton gauze pads.

       

      Conclusion:

      The adhesion disposition of dressings with an aluminium coating could be quantified and evaluated using a special tissue substitute. It could be shown that the aluminium-coated dressings* tested demonstrated a significantly lower adhesion than simple cotton gauze pads.

      Products Metalline
    2. Poster

      ASSESSMENT OF THE COMPATIBILITY OF A NON-ADHERING DRESSING AND CNP FOAM DURING NPWTIN VITRO

      Poster presented at EWMA 2016 11.05.2016 Bremen, Germany
      Products Lomatuell Pro
    3. Journal article

      Multinational, pilot audit of a Velcro adjustable compression wrap system for venous and lymphatic conditions

      Journal of wound care 2016 25(9) 513520

      OBJECTIVE

      The aim of this small pilot audit was to record the performance of an adjustable Velcro compression wrap, ReadyWrap, and the experiences of patients and health-care professionals using the system as a self-care option for the management of venous and lymphatic leg conditions in both the treatment and maintenance phases.

      METHOD

      This audit was held within a 4-week review period. Participants included venous leg ulcer (VLU) patients with and without oedema, and patients with lymphoedema. Where open wounds were present they were managed with debridement, skin care and dressings according to clinical need. Lymphoedema patients received manual lymphatic drainage and skin care regimens as per standard practice. The Velcro system evaluated formed part of a treatment pathway with compression bandages and/or compression hosiery as clinically indicated. Patients, carers and health-care professionals applied the garments following assessment and training. Objective data recorded included change in circumferential measurements and improvement in wound status. Observation of health-care professionals, patients and carers with regard to the comfort and ease of application/removal of the device were recorded.

      RESULTS

      There were 17 patients included in the audit. Within the 4-week period a reduction in limb circumference was recorded in all cases. Improvements in open wounds were recorded in most cases. Following the 4-week audit period 94% of the application of the device was performed by either the patient (59%) or the carer (35%) thereby reducing the health-care professional contact that was required for application.

      CONCLUSION

      Early results in this small audit demonstrate that this adjustable Velcro compression wrap may provide a simple, clinically effective and patient-acceptable solution for self-care with compression. Use of this type of device could have the potential to reduce overall health-care burden by reducing necessary skilled treatment visits and/or cost while still achieving good clinical outcomes. Further studies are required to confirm this pilot study and provide additional data.

      PMID 27608512
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    4. Journal article

      The difficulty and the solution of compression therapy in a healed venous leg ulcer

      British journal of community nursing 2016 21 Suppl 9 348

      Continuing preventative treatment once a venous ulcer is healed is fraught with dangers, with the most common problem being the inability of the wearer or their carer to apply compression therapy. A new novel compression modality has been introduced to solve the dilemma of applying compression once an injury has healed. This compression is also time-saving for practitioners who wish to heal leg ulcers. This will have an impact on the time restrictions of practice and district nurses-who have a 10-15 minute slot to dress and bandage their patients' venous ulcers.

      PMID 27594312
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    5. Journal article

      In vitro Evaluation of the Cleansing Effect of a Monofilament Fiber Debridement Pad Compared to Gauze Swabs

      Skin pharmacology and physiology 2016 29(6) 318323

      BACKGROUND

      Removal of nonvital tissue is an accepted method to eradicate biofilms and to stimulate wound healing. Debridement using a monofilament polyester fiber pad has clinically been shown to be effective as well as pain and trauma free.

      METHODS

      For in vitro determination of the cleansing capacity of this product compared to gauze swabs, a wound debridement model was used with glass plates coated with a bovine serum albumin solution, stained with hematoxylin. Both products were moistened and fixed to a weight connected to a regulated motor and were then pulled over the holding device with the coated glass plate under standardized conditions (power = 0.067 N/cm2, velocity = 1.6 cm/s).

      RESULTS

      At a low coating concentration (0.5%) both products were equally effective, but at a high concentration (1.5%) cleansing did not occur after 5 wipes. When wiping the plates 15 times, the debridement pad cleansed significantly (p < 0.001) better than gauze. When consecutively wiping 4 coated plates with a single debridement pad or swab, the pad exhibited and maintained a significantly higher cleansing capacity while gauze quickly lost its effect.

      CONCLUSION

      Our in vitro test results indicated a higher cleansing capacity of the debridement pad compared to gauze swabs.

      Products Debrisoft Pad
      PMID 28095386
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    6. Journal article

      Transgastric endoscopic vacuum therapy with a new open-pore film drainage device in a case of infective pancreatic necrosis

    7. Journal article

      Wundantiseptik: Evidenz, Indikationen, Wirkstoffauswahl und Perspektiven

      ARS MEDICI 2016 9 419228
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    8. Journal article

      Endoskopische Vakuumtherapie beim Boerhaave-Syndrom

      Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2016 87(8) 676682

      INTRODUCTION

      Operative and interventional treatment of Boerhaave's syndrome include closure of the esophageal defect and drainage of the septic focus. Initial reports on the use of endoscopic vacuum therapy (EVT) of Boerhaave's syndrome are now available. This article describes the experiences gained from the clinical application in two patients using this new surgical endoscopic procedure. The current literature regarding treatment of Boerhaave's syndrome is presented.

      MATERIAL AND METHODS

      Open-pore drainage is endoscopically placed either through the transmural defect in the extraluminal wound cavity (intracavitary EVT) or overlapping the defect into the esophageal lumen (intraluminal EVT). The application of a negative pressure results in active drainage directed to the lumen and simultaneously in defect closure. Through these therapeutic measures the perforation defect and the septic focus can be healed. Open-pore drains are manufactured from drainage tubes and open-pore foam or an open-pore film.

      RESULTS

      In both patients the distal esophageal perforation defects were completely healed using EVT. In 1 patient the treatment with EVT alone lasted 8 days. For the second patient EVT was combined with an open thoracotomy for decortication of pleural empyema. The treatment with EVT lasted 23 days and 1 cycle of EVT was carried out with an new open-pore film drainage (OFD). Surgical treatment to close the defect or an esophageal resection was not necessary for both patients. In the currently available studies and single case reports of ETV for Boerhaave's syndrome, 11 patients (84 %) of a total of 13 patients have been successfully treated.

      CONCLUSION

      First clinical experiences have demonstrated that with EVT draining of the septic focus and closure of the Boerhaave defect at the gastroesophageal junction can be achieved. The EVT is an organ-preserving endoscopic surgical treatment, which can be an alternative and complementary to traditional surgery.

      PMID 27259548
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    9. Journal article

      Hypercoagulant Abdominal Swabs in Cardiac Surgery: Potential Problems and Background

      The Thoracic and cardiovascular surgeon 2016 64(7) 589595

      Background During cardiac surgery with heart-lung-machine support, abdominal swabs are routinely used to adsorb blood from the operation field. In part, abdominal swabs exhibit procoagulant activity, which is usually considered harmless. However, coagulation induction and abnormal clot formation on the surface of abdominal swabs in the operation field may, if the blood is retransfused into the extracorporeal circuit, lead to severe thromboembolic complications. The aim of the present study was to elucidate the origin of the unexpected blood clotting upon contact with hypercoagulant swabs. Methods The coagulant properties of three abdominal swabs were characterized using a simple clotting test and human whole blood, which was anticoagulated with different heparin concentrations. Eluates prepared from the abdominal swabs and the color stabilizer polydiallyamine (PDAA) were incubated with blood and blood clotting was investigated. Furthermore, the effects of the abdominal swabs on blood clotting time and on heparin were investigated. Results Our data show that the three abdominal swabs as well as the respective eluates exhibit distinctive coagulant properties. The abdominal swab with the highest hypercoagulant effect significantly reduced blood clotting time and also led to a reduction in free heparin. PDAA does not induce activation of the coagulation system. Conclusion The data indicate that the hypercoagulant swab reduces the clotting time and the concentration of free heparin. Abdominal swabs used during complex cardiac surgery with heart-lung-machine support should definitely be tested for their coagulant properties using appropriate tests before clinical applications, as it cannot be specified what leads to their hypercoagulant property.

      PMID 26765244
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    10. Journal article

      How to manage lower limb complications