Clinical Newsletter
Regular updates on our latest clinical studies.
Our research and development teams operate at a global level and generate synergies from our collective expertise and by drawing on related disciplines. We are also constantly exchanging information at an international level with independent technical institutions, key opinion leaders and multipliers in order to be able to ensure cooperation and knowledge management of the highest order. As part of this process, we also conduct extensive research, the results of which we continually present in workshops, at conferences and symposiums - either in documentation or talks given by our cooperation partners - and also publish in renowned scientific journals. This database contains a large number of these evidence-based scientific articles, most of which have been evaluated by independent assessors:
Introduction:
A new, non-silver cellulose-based wound dressing has demonstrated to be effective against biofilms and preventing bacterial penetration. The fibres of the new dressing are coated with a novel antibiofilm formulation containing PHMB (polyhexanide).
Methods:
The biofilm method used in the study was based on a gauze model developed by Bowler and Parsons, 2016. 1 In the first step, circular pieces of 1.6 cm sterile gauze were punched out before being transferred into sterile 100 ml Erlenmeyer flasks and submerged in 25 ml of liquid bacterial culture containing either S.aureus or P.aeruginosa at approximately 1-5 x 105 CFU/ ml. The Erlenmeyer flasks were subsequently shaken for 48h in order to coat the gauze with a mature biofilm.
Each piece of gauze was then placed onto an individual agar plate and covered with a 3.2 cm disk of the test dressing and wetted with 1.5 ml of simulated wound fluid. Finally, the test dressings were covered with a piece of silicon dressing and the plate closed with parafilm.
Bacterial penetration testing was performed by saturating 4.2 x 4.2 cm dressing samples with aliquots of SWF. Dressings were subsequently incubated (pre-conditioned) at 37°C for 6-days. After this period, the cut samples were placed onto fresh agar plates and inoculated with bacterial suspension containing 1x 108 CFU/ml evenly around the edge of the dressing. Petri dishes were then incubated for 24h, the dressings removed and plates inspected for growth.
Results:
The new, non-silver wound dressings completely killed all the bacteria in the both the S. aureus and P.aeruginosa biofilms. In comparison, a silver based competitor dressing did not remove the biofilm for either bacteria.
Bacterial penetration was also prevented in the new dressing.
Discussion:
Initial evidence would suggest the new non-silver dressing is highly effective against biofilms and preventing bacterial penetration.
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